Evaluations of scientific productions are traditionally made by h-index which is defined by only the most cited publications neglecting significant part of scientists’ productions. Also, h-index can be rapidly increased by networking effects (friendship citations) leading to critical evaluation aspect of scientific productivity under reduced conception and frequent manipulation ways. This calls for bibliometric revisions through more integrative and more robust ways. In this framework, a new simplex simulation approach was developed for functional evaluations of scientific productions by highlighting regulation trends between structural variables of publications, and by considering whole sets of papers. Initially, publications are classified according to predefined criteria; then, their contents are structurally characterized by relative levels of production and cooperation variables including the numbers of pages, figures, tables, authors, affiliations, countries, etc. Using Scheffé’s mixture designs, simplex simulation iteratively combined structural variability of different publications’ classes by varying their relative weights. In response to combinations, a complete set of smoothed barycentric publication patterns was calculated. This response matrix represented system backbone from which regulation trends between production and cooperation variables were highlighted for different publications’ class. Application was illustrated by analyzing populations of Tunisian biological and medical researchers initially classified into 6 classes combining three h-index ranges with two citation levels of papers ( h or < h). Production variables showed positive trends leading to higher vs lower productivity ratios in scientists’ classes associated with lower and higher h-index ranges, respectively. Moreover, papers’ citations were improved by slight increase vs significant decrease of coauthors’ numbers, respectively. These functional results highlighted production ratios and trends that are inaccessible by h-index. By its integrative and flexible aspects, simplex simulation approach calls for developing international projects aiming for scientific productivity analyses at different scales (scientists, institutions, countries, etc.) by considering open classification criteria.