Title: Rodenticidal activity of some quinoline-based heterocycles derived from hydrazide hydrazone derivative

Abstract

Quinolines are found in a variety of synthetic heterocycles to enhance their pharmacological properties such as antiviral, anticancer, anti-inflammatory, and insecticidal activity. In addition to anticoagulant medication. Noteworthy, cilostazol (6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]- 3,4-dihydro-2-(1H)-quinolinone), has been known to inhibit phosphodiesterase type 3 (PDE III), and increasing the intracellular level of cAMP and activating protein kinase A (PKA). The cAMP/PKA pathway was reported to potentiate the opening of mitochondrial Ca2+- activated K+ (mitoKCa) channels and confers cardioprotection. In turn, cilostazol has been reported to directly activate sarcolemmal large conductance Ca2+-activated K+ channels. Also, the possibility of cilostazol was tested towards opening mitoKCa channels and protecting hearts against ischemia/reperfusion injury. 2-cyano-N'-((2-oxoquinolin-3-yl)methylene) ethanohydrazide (3) was reported and converted into some quinoline-based heterocycles with the objective of evaluating them as potential rodenticidal agents against first and second generation anticoagulants like chlorophacinone, brodifacoum, warfarin, and cilostazol Anticoagulant rodenticides (ARs) when ingested, these poisons cause internal bleeding by inhibiting the production of blood-clotting agents.To receive a lethal dose of first-generation anticoagulant rodenticides (FGARs), the rodent must consume multiple portions of the bait. Second-generation anticoagulant rodenticides (SGARs) are extremely toxic, and rodents can receive a lethal dose in a single feeding. A poisoned rat makes easy prey, which can lead to secondary poisoning in predators such as owls and other raptors that eat the rodent. The experimental results of the newly synthesized compounds new generation are summarized. A series of quinoline-based heterocycles like chromene and pyridine derivatives was screened as rodenticidal agents against second-generation anticoagulants. Three compounds 5, 6, and 7 exhibited a stronger rodenticidal effect than the other compounds which were examined by oral toxicity of new generation against (Chlorophacinone, Brodifacoum, and Warfarin) anticoagulants to laboratory rat. This may be due to their presence in more tautomeric structures. Thus, they may serve as rodenticidal products.